March 10, 2026 · Menopause (New York, N.Y.) · DOI: 10.1097/GME.0000000000002763

Independent and joint associations of loneliness and social isolation with subjective cognitive decline in perimenopausal women

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This study investigates the independent and joint effects of loneliness and social isolation on subjective cognitive decline (SCD) in perimenopausal women. Analyzing data from 903 participants, the authors found that both loneliness and social isolation are significantly associated with SCD, with those experiencing moderate to severe levels of both factors showing the highest risk for severe SCD. The findings highlight the importance of social connections in cognitive health and suggest potential avenues for psychosocial interventions.

Xiaohe Lin, Xiangyu Zhao, Xinyi Liu, Di Zhao, Juan Guo, Ping Li

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