March 5, 2026 · Gynecologic oncology · DOI: 10.1016/j.ygyno.2026.01.770

Demographics, clinicopathological features, and survival outcomes of women with endometrial neuroendocrine tumors

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The authors aimed to analyze the demographics, clinicopathological features, and survival outcomes of women with endometrial neuroendocrine tumors (ENETs) to evaluate how these factors influence treatment outcomes. Their study found that ENETs are often diagnosed at advanced stages and that combined adjuvant chemotherapy and radiotherapy significantly improve progression-free and overall survival. Additionally, the research highlighted common genetic mutations and the prevalence of mismatch repair deficiency in these tumors, suggesting potential therapeutic targets for future treatment strategies.

Morgan Bou Zerdan, Reem Saab, Larissa A Meyer, Mark F Munsell, Jeffrey A How, Pamela T Soliman

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