March 2, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102050

Cost effectiveness analysis of immunotherapy regimens currently approved in advanced or recurrent endometrial cancer: An analysis of the NRG-GY 018, RUBY, and DUO-E trials

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The authors aimed to evaluate the cost-effectiveness of FDA-approved immunotherapy regimens combined with chemotherapy for advanced or recurrent endometrial cancer, specifically in mismatch repair deficient (dMMR) and proficient (pMMR) cohorts. Their analysis revealed that pembrolizumab and durvalumab are more cost-effective than dostarlimab, primarily due to differences in maintenance therapy duration, while immunotherapy appears less cost-effective for the pMMR population.

Alex A Francoeur, Su-Ying Liang, Brittany File, Eunji Choi, Max Brameld, Michael T Richardson, Caitlin R Johnson, Daniel S Kapp, Krishnansu S Tewari, John K Chan

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