March 19, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102057

Neoadjuvant chemotherapy in locally advanced clear cell carcinoma of the cervix leading to complete disease resolution; a case report

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This case report explores the effectiveness of a novel neoadjuvant chemotherapy regimen (cisplatin/paclitaxel/pembrolizumab/bevacizumab) in treating a 46-year-old woman with locally advanced clear cell carcinoma of the cervix, a rare and challenging form of cervical cancer. The authors aim to determine whether this alternative treatment approach can lead to improved outcomes, as evidenced by the patient's complete disease resolution following treatment and surgery. They conclude that further research is warranted to establish optimal neoadjuvant therapies for this difficult-to-treat cancer type.

Emily Fronk, Michelle Whittum, Dijana Poljak, Ashlee Smith

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