Predicting concurrent endometrial carcinoma in women with endometrial intraepithelial neoplasia without preoperative suspicion of malignancy.
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This retrospective cohort study of 124 women with endometrial intraepithelial neoplasia (EIN) who underwent hysterectomy asked which preoperative variables predict concurrent endometrial carcinoma when no malignancy was suspected beforehand. Type 2 diabetes, age, body mass index, and diagnostic method (with hysteroscopy-guided sampling or D&C associated with lower odds than pipelle biopsy) formed a nomogram with good apparent discrimination (AUC 0.828; optimism-corrected AUC 0.784), though 14.5% of cases had carcinoma. The authors conclude that external and prospective validation is needed before clinical use.
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