ALKBH5-Dependent m⁶A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

The authors investigate the role of ALKBH5, an m⁶A demethylase, in cardiac aging and its underlying mechanisms. They find that increased ALKBH5 expression leads to reduced m⁶A levels and downregulation of SLC38A3, which contributes to impaired glutamine metabolism and cardiac dysfunction. This study highlights the ALKBH5-SLC38A3 axis as a significant regulator of aging-related cardiac phenotypes, suggesting it as a potential target for therapeutic intervention.