Sotatercept Improves Right Heart Mechanics Despite Reduced Myocardial Contractility in Pulmonary Arterial Hypertension: A Prospective Exercise Hemodynamic Study
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The authors aimed to evaluate the effects of sotatercept on right ventricular (RV) mechanics in patients with pulmonary arterial hypertension (PAH), specifically examining load-independent measures of RV contractility and RV-PA coupling during rest and exercise. The study found that while sotatercept reduced RV contractility and pulmonary artery afterload, it preserved RV-PA coupling and improved global right heart performance, suggesting a favorable adaptation of the right heart mechanics despite decreased contractility. These findings indicate that sotatercept may enhance right heart function in PAH by optimizing the relationship between contractility and afterload.
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