Reimplantation in 2-Stage Exchange: Breaking the Dogma of the 2-Week Antibiotic Holiday

The authors investigate the optimal timing for reimplantation in patients undergoing 2-stage exchange revision for periprosthetic joint infection, questioning the necessity of a 2-week antibiotic holiday prior to reimplantation. They suggest that a combination of clinical signs and declining serological markers may be more effective in guiding reimplantation timing than traditional metrics, and highlight the potential benefits of continuous antibiotic therapy in improving outcomes. The study calls for the development of a reliable tool to aid in determining the best timing for reimplantation.