September 13, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)01555-2

Most-favoured-nation pricing for prescription drugs in US Medicare: a cohort study

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This study aimed to model the impact of the most-favoured-nation payment models (GLOBE and GUARD) on Medicare spending for prescription drugs in the U.S. The findings indicated that these models could reduce net Medicare spending by approximately $5.2 billion (16.1%) under GLOBE and $6.4 billion (17.6%) under GUARD, with significant potential savings exceeding annual sales in reference countries, raising concerns about manufacturer behavior in response to these pricing models.

Thomas J Hwang, Simon Hediger, Advaita Krishnan, Christopher L Cai, Aaron S Kesselheim, Kerstin Noelle Vokinger

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