September 11, 2026 · BMJ (Clinical research ed.) · DOI: 10.1136/bmj-2026-100499

Exploring high priority potentially inappropriate prescribing cascades in older adults: population level retrospective cohort study

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The authors aimed to identify and prioritize potentially inappropriate prescribing cascades among older adults using a population-level retrospective cohort study in Ontario, Canada. They found 24 prescribing cascades that met specific criteria for prevalence, incidence, and temporal association, highlighting the need for targeted interventions to improve medication safety in this population. The findings can inform prescribing practices and policy development to mitigate risks associated with inappropriate medication use in older adults.

Paula A Rochon, Peter C Austin, Jerry H Gurwitz, Wei Wu, Lavina Matai, Tracy Zhang, Zhiyin Li, Rachel D Savage, Andrea Gruneir, Joyce Li, Denis O'Mahony, Mirko Petrovic, Antonio Cherubini, Graziano Onder, Shelley A Sternberg, Lisa M McCarthy, Kieran Dalton, Christina E Reppas-Rindlisbacher, Nathan M Stall, Sharon-Lise T Normand, Vasily Giannakeas

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