September 10, 2026 · Pediatric nephrology (Berlin, Germany) · DOI: 10.1007/s00467-026-07546-6

Neonatal acute kidney injury and the patent ductus arteriosus

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The authors investigate the relationship between patent ductus arteriosus (PDA) and neonatal acute kidney injury (AKI) in premature infants, questioning how ductal patency and its management may influence kidney health. They highlight that while PDA is linked to systemic hypoperfusion and may exacerbate AKI, current therapeutic interventions can also pose risks to renal function. The review aims to clarify the physiological implications of PDA in the context of neonatal AKI and the factors contributing to kidney injury in this vulnerable population.

Dermot Wildes, Siobhán Coughlan, Sally Cahill, Aoife Cleary, Atif Awan, Michael F Riordan, Afif El-Khuffash, Michael A Boyle

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