Is there an interaction between hypertension and proteinuria in pediatric chronic kidney disease progression? Evidence from the SP-CKD-Kids cohort

The authors aimed to investigate whether hypertension and proteinuria interact multiplicatively to influence the progression of chronic kidney disease (CKD) in a pediatric population. In their study of 254 children with CKD stages 3-4, they found that both hypertension and proteinuria were independent risk factors for CKD progression, with the highest risk observed in patients with both conditions. However, the analysis did not reveal a statistically significant interaction between hypertension and proteinuria, suggesting that while both factors are important, their combined effect may not be as straightforward as previously thought.