Surveillance for Hepatocellular Carcinoma in Patients at High Risk

The authors investigate effective surveillance strategies for hepatocellular carcinoma (HCC) in high-risk patients, emphasizing the limitations of current standard practices, such as semiannual ultrasound and serum α-fetoprotein testing. They explore alternative approaches, including biomarker panels and abbreviated MRI protocols, which may offer improved sensitivity and cost-effectiveness for specific patient subgroups. Additionally, the paper addresses the barriers to optimal surveillance implementation in clinical settings and advocates for personalized, risk-adapted surveillance strategies.