September 1, 2026 · Annals of emergency medicine · DOI: 10.1016/j.annemergmed.2026.07.004

Dexmedetomidine Continuous Infusion to Maintain Sedation in Severely Agitated Adolescents in the Emergency Department

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The authors aimed to evaluate the effectiveness of dexmedetomidine continuous infusion as a bridge therapy for severely agitated adolescents in the emergency department awaiting psychiatric treatment. In a retrospective study of 20 patients, they found that 45% required additional sedation despite the infusion, suggesting that while dexmedetomidine may be feasible for managing severe agitation, further research is needed to optimize its use in this population.

Giorgio Cozzi, Alessandro Zago, Alberto J Di Mascio, Federico Poropat, Egidio Barbi, Alessandro Amaddeo

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