August 21, 2026 · Gynecologic oncology · DOI: 10.1016/j.ygyno.2026.08.015

Early-phase vs. late-phase clinical trials in gynecologic oncology: Trends in trial completion, reporting, and enrollment of racial and ethnic minority groups

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The authors aimed to compare early-phase and late-phase clinical trials in gynecologic oncology regarding trial completion rates and the enrollment of racial and ethnic minority groups (REMGs). They found that early-phase trials had higher publication rates, while late-phase trials were more likely to report race/ethnicity data, although early-phase trials enrolled a greater proportion of REMGs. The study highlights the need for further investigation into the low publication rates and under-enrollment of REMGs in late-phase trials to address these disparities.

Michael T Richardson, Danika Barry, Jecca R Steinberg, Kai Holder, Vineeth Thirunavu, Naixin Zhang, Brandon E Turner, Christopher J Magnani, Anna Marie P Young, Connie F Lu, Natalie A Squires, Jill N Anderson, Joshua Cohen, Beth Y Karlan, John K Chan, Daniel S Kapp, Dario R Roque, Ritu Salani

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