Multicentric Longitudinal Performance Monitoring of Different Prenatal Cell-Free DNA Screening Technologies in Belgium
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The authors aimed to evaluate the real-world longitudinal performance of various prenatal cell-free DNA screening technologies in Belgium, specifically assessing their positive predictive values (PPVs) for detecting fetal trisomies 21, 18, and 13. Over three years, they recorded outcomes from 1158 confirmatory diagnostic tests, finding that laboratory-developed tests (LDTs) generally outperformed commercial tests in terms of PPVs. The study highlights the importance of understanding these performance differences, as they significantly affect both pregnant individuals and the national healthcare system.
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