Fetal Brain Abnormalities in Trisomy 21 and Associated Neurodevelopmental Outcome: Key Factors to Identify Differences in Neurodevelopmental Outcome?
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The authors aim to investigate the neuropathological changes in fetuses with Trisomy 21 (T21) and their impact on neurodevelopmental outcomes, comparing brain patterns in T21 fetuses to healthy controls. The study found that T21 fetuses exhibited significantly more brain abnormalities, with specific conditions like cerebellar hypoplasia and widened subarachnoid fluid spaces being linked to poorer neurodevelopmental outcomes. The findings highlight the need for careful prenatal counseling regarding the implications of these brain abnormalities in T21.
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