Diabetes-Induced Dysregulation of Purinergic Signaling in the Bladder Mucosa: Accelerated ATP Hydrolysis and Impaired Adenosine Uptake Promote Underactive Bladder Phenotype

The authors investigate the molecular mechanisms leading to excessive extracellular adenosine accumulation in the bladder mucosa of mice with type 2 diabetes, which may contribute to an underactive bladder phenotype. They find that accelerated ATP hydrolysis and impaired adenosine uptake due to decreased ENT1 expression are key factors driving this dysregulation. These findings suggest that the elevated adenosine levels inhibit detrusor muscle contractility, exacerbating bladder underactivity in diabetic conditions.