A Vagal-Renal-Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury
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The authors investigate whether afferent vagus nerve stimulation (aVNS) can mitigate ischemic acute kidney injury (AKI) by modulating renal sympathetic nerve activity (RSNA) through central autonomic circuits and splenic neuroimmune signaling. Their findings demonstrate that aVNS effectively suppresses RSNA, preserves kidney function, and requires splenic involvement for optimal protective effects after ischemic injury. This study suggests a potential therapeutic approach for AKI by targeting vagal-autonomic pathways.
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