Impaired Metabolic Remodeling Characterizes Injured Niches during Post-ischemic Kidney Repair
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The authors investigate how the tissue microenvironment affects the transition from acute kidney injury to chronic kidney disease, specifically focusing on the metabolic characteristics of injured niches. Using a multimodal spatial omics approach, they identify distinct metabolic abnormalities in both failed-repair and seemingly healthy proximal tubule cells within injured areas, highlighting defects in oxidative phosphorylation and fatty acid β-oxidation that extend beyond visibly damaged cells. This study underscores the importance of the metabolic landscape in kidney repair processes following ischemia-reperfusion injury.
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