Risk-Adapted Use of Adjuvant Systemic Therapy After Nephrectomy for Renal Cell Carcinoma: A Population-Based Study in the Post-approval Era
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The authors aimed to characterize the real-world use of adjuvant systemic therapy (AST) in eligible renal cell carcinoma (RCC) patients following nephrectomy and to determine if treatment allocation aligns with established high-risk tumor characteristics. Their analysis of the SEER database revealed that while AST use increased from 13% in 2018 to 36% in 2022, only 18% of eligible patients received AST, with higher usage associated with adverse tumor features such as T4 stage, tumor grade 4, and N1-2 stage. Despite the increase in AST administration, it remained underutilized, particularly among high-risk patients.
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