August 4, 2026 · Menopause (New York, N.Y.) · DOI: 10.1097/GME.0000000000002874

Inflammatory and immune biomarkers over midlife and future cognition in women: the SWAN HDL Ancillary Study

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The authors investigate the associations between systemic inflammatory (GlycA) and immune (C3 and C4) biomarkers measured during midlife and future cognitive performance in women, particularly around the menopause transition. They find that higher baseline GlycA is linked to worse working memory, while higher baseline complement factor 4 and increases in C3 and C4 may offer cognitive protection. The study suggests that addressing inflammation and immune function during this period could help preserve cognitive health in women.

Meiyuzhen Qi, Carol A Derby, Daniel Rader, Imke Janssen, Emma Barinas-Mitchell, Maria M Brooks, Chung-Chou H Chang, Arun S Karlamangla, Dan McConnell, Sybil Crawford, Samar R El Khoudary

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