Mitochondria-targeted therapeutic strategies in assisted reproduction: challenges and potential solutions

The authors investigate the role of mitochondria in oocyte competence and early embryonic development, particularly how mitochondrial dysfunction contributes to reproductive challenges such as diminished ovarian reserve and impaired embryo development. They explore various mitochondria-targeted therapeutic strategies and highlight the need for more precise, well-defined interventions, as current clinical outcomes are inconsistent due to limitations in study design and therapeutic timing. The paper emphasizes the importance of rigorous safety evaluations and the development of standardized approaches to enhance the efficacy of these therapies in assisted reproduction.