LRPPRC deficiency impairs trophoblast function through disrupted phosphatidylinositol metabolism in recurrent pregnancy loss

The authors investigate whether leucine-rich pentatricopeptide repeat-containing protein (LRPPRC) is involved in recurrent pregnancy loss (RPL) and the underlying mechanisms. They find that LRPPRC deficiency disrupts phosphatidylinositol metabolism, leading to impaired trophoblast viability, increased apoptosis, and oxidative stress, with low preconception serum levels of specific phosphatidylinositol species predicting subsequent miscarriage in women with RPL. The study suggests that phosphatidylinositol could serve as a mechanistic biomarker and therapeutic target in RPL.