July 31, 2026 · Mayo Clinic proceedings · DOI: 10.1016/j.mayocp.2026.07.023

Cardiac Troponin in Autoimmune Rheumatic Diseases: Lights and Shadows

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This review investigates the role of cardiac troponin (cTn) as a biomarker for cardiac involvement in autoimmune rheumatic diseases (ARDs), addressing its diagnostic and prognostic value amid the complexities of interpreting cTn elevations due to various factors. The authors highlight the potential of high sensitivity cTn assays to detect myocardial injury and predict cardiovascular events, while also acknowledging the challenges posed by comorbidities and analytical interferences. Ultimately, they emphasize the need for careful interpretation of cTn results to enhance diagnosis and treatment strategies in ARD patients.

Anna Cuberli, Beatrice Moccaldi, Michele Strosio, Marco Binda, Andrea Benini, Francesco Tona, Alida L P Caforio, Martina Perazzolo Marra, Cristina Basso, Martina Montagnana, Roberta Ramonda, Domenico Corrado, Yannick Allanore, Allan S Jaffe, Laura De Michieli, Elisabetta Zanatta

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