Navigating Protein-Losing Enteropathy: A Stepwise Approach for Primary Care Clinicians

The authors aim to provide primary care clinicians with a comprehensive guide for recognizing and managing protein-losing enteropathy (PLE), a syndrome characterized by excessive loss of serum proteins through the gastrointestinal tract. They discuss the pathophysiology, clinical presentation, diagnostic strategies, and the importance of early identification to address nutritional and other complications, as well as to uncover treatable underlying conditions. The review emphasizes a stepwise approach to evaluation and management to improve patient outcomes.