Modeling cardiovascular risk across the menopause transition: a synthetic cohort study

The authors aimed to develop a synthetic cohort model to simulate cardiovascular risk trajectories during the menopause transition, particularly focusing on the impact of menopausal hormone therapy (MHT) and various risk factors. Their findings indicate significant increases in atherosclerotic cardiovascular disease (ASCVD) risk post-menopause, with a notable rise in the proportion of women classified as high-risk. This model serves as a valuable tool for understanding and predicting cardiovascular risk in women undergoing menopause.