July 28, 2026 · Menopause (New York, N.Y.) · DOI: 10.1097/GME.0000000000002854

Weight loss interventions and sexual function in midlife women: the emerging role of glucagon-like peptide-1 receptor agonists

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This review investigates the effects of glucagon-like peptide-1 (GLP-1) receptor agonists on sexual function in midlife women, particularly in the context of obesity and menopause. The authors highlight that while GLP-1 therapies can lead to significant weight loss and metabolic benefits, they may also negatively impact sexual desire and arousal. The review calls for more systematic clinical studies to better understand these effects and emphasizes the importance of assessing sexual health in women undergoing GLP-1 treatment.

Regina Castaneda, Diego Sepulveda, Maria D Hurtado Andrade, Chrisandra L Shufelt, Stephanie S Faubion

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