July 23, 2026 · Journal of hepatology · DOI: 10.1016/j.jhep.2026.06.037

Pushing the boundaries of liver resection for liver cancer

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The authors explore how advancements in surgical techniques and oncological principles can expand the eligibility for liver resection in patients with hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), particularly in cases previously deemed unresectable. They emphasize the importance of assessing future liver remnant and functional reserve while integrating systemic and locoregional therapies to improve surgical outcomes. Additionally, the paper discusses the potential impact of new molecular biology insights and treatment strategies on enhancing resectability for liver cancer.

Gonzalo Sapisochin, Grainne M O'Kane, Anudari Zorigtbaatar, Albert Chi Yan Chan, Sherrie Bhoori

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