Corticosteroid Therapy for Drug-induced Liver Injury: Mind the Gap!

The authors investigate the efficacy and safety of corticosteroid therapy in treating drug-induced liver injury (DILI), particularly in the context of checkpoint inhibitor-induced liver injury (ChILI). They highlight the lack of evidence supporting corticosteroids' ability to accelerate recovery or improve survival outcomes in DILI, while also noting the potential for adverse effects and delayed resolution when used inappropriately. The paper suggests that corticosteroid-sparing strategies are often more effective and safer for managing ChILI.