The changing epidemiology of primary liver cancer in the 21^st century

The authors investigate the changing epidemiology of primary liver cancer in the 21st century, highlighting a significant increase in incident cases and deaths from 2000 to 2023, despite a prior decline in age-standardized rates. They note a concerning rebound in hepatitis B and C-related liver cancer since 2020, alongside a rapid rise in cases associated with metabolic dysfunction. The study underscores the need for ongoing public health efforts to address the diverse and evolving causes of liver cancer globally.