August 4, 2026 · Journal of hepatology · DOI: 10.1016/j.jhep.2026.02.030

Systemic therapy of biliary tract cancer: The road to personalised strategies

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The authors explore the current landscape and future directions of systemic therapy for biliary tract cancers (BTC), aiming to understand how personalized treatment strategies can improve patient outcomes. They highlight the role of precision medicine, particularly targeted therapies for specific genetic mutations, and the challenges in implementing these strategies due to issues like biomarker testing and resistance biology. The review emphasizes the need for optimized diagnostics and innovative trial designs to advance personalized care in BTC.

Angela Lamarca, James J Harding, Do Youn Oh

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