July 21, 2026 · Hormone research in paediatrics · DOI: 10.1159/000553585

Real-world growth outcomes and safety of vosoritide in children with achondroplasia: a Brazilian single center 24 monhts experience

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The authors aimed to evaluate the effects of vosoritide on growth, body proportionality, and safety in children with achondroplasia over a 24-month period in a real-world clinical setting. The study found significant increases in height velocity and height SDS, particularly at 24 months, but noted that individual responses varied and body proportionality remained unchanged. Despite some patients experiencing hypertrichosis, the treatment was well tolerated, indicating its potential for clinical use.

Ana Paula Neves Bordallo, José Gregorio Dominguez Alfonso, Juan Llerena, Tatiana Sa Pacheco Carneiro Magalhaes, Henrique Botti, Dafne Dain Gandelman Horovitz, Paulo Ferrez Collett-Solberg

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