July 15, 2026 · Journal of the American College of Cardiology · DOI: 10.1016/j.jacc.2026.06.003

Aspirin Withdrawal in Patients With Coronary Artery Disease

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The authors investigate the implications of aspirin withdrawal in patients with coronary artery disease (CAD), particularly those who also require oral anticoagulation (OAC). They aim to determine whether a strategy of temporarily using dual antiplatelet therapy followed by aspirin withdrawal can reduce bleeding risks without compromising ischemic protection, while also considering various patient-specific factors and clinical settings. The paper reviews existing evidence and guidelines to provide practical recommendations for implementing this strategy in CAD management.

Mattia Galli, Davide Capodanno, Jurrien Ten Berg, Larisa H Cavallari, Sunil V Rao, Pedro A Lemos, Marco Valgimigli, Mario Gaudino, Adnan Kastrati, P Gabriel Steg, Renato D Lopes, C Michael Gibson, Roxana Mehran, Dominick J Angiolillo

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