Cross-Ancestry Proteogenomic Analyses Identified New Therapeutic Insights for Ischemic Heart Disease
Listen to this summary
The authors aimed to identify novel drug targets for ischemic heart disease (IHD) by conducting cross-ancestry proteogenomic analyses using cis-acting single nucleotide polymorphisms (cis-pQTLs) in diverse populations. Their study found 54 unique proteins associated with IHD etiology, with significant insights into lipid-driven chronic inflammation as a contributing factor. The results suggest that future treatment strategies should focus on targeting multiple lipid and inflammation pathways to enhance IHD management beyond current statin therapies.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of the American College of Cardiology
View all →Aug 5, 2026 · Journal of the American College of Cardiology
Impact of Left Ventricular Unloading on Hemodynamics and Stunning in Complex PCI: A CHIP-BCIS3 Substudy
Jul 29, 2026 · Journal of the American College of Cardiology
Clinical Considerations in Management of Hypertrophic Cardiomyopathy in Pregnancy: JACC State-of-the-Art Review
Jul 29, 2026 · Journal of the American College of Cardiology
Compound Exposure to Extreme Heat and Substantial Landscape Fire-Sourced Air Pollution on Cardiovascular Mortality
Jul 29, 2026 · Journal of the American College of Cardiology
Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients
Jul 29, 2026 · Journal of the American College of Cardiology
Health Status Outcomes 7 Years After Transcatheter or Surgical Aortic Valve Replacement in Low-Surgical Risk Patients With Aortic Stenosis
Jul 22, 2026 · Journal of the American College of Cardiology
Refining the Role of Beta-Blockers in Cardiovascular Medicine
More in Internal Medicine
View all →Aug 9, 2026 · American heart journal
Recurrent myocardial infarction identified by centralized troponin review: Insights from the MINT trial
Aug 8, 2026 · JACC. Clinical electrophysiology
LMNA Deficiency Reveals a Role for SK3 Channel Dysfunction in Atrioventricular Block
Aug 8, 2026 · JACC. Clinical electrophysiology
Atrial Fibrillation Initiation Arises From Reentry at Patient-Specific Regions With Steep Repolarization Gradients Identified During Sinus Rhythm
Aug 7, 2026 · American heart journal
HPS-4/TIMI 65/ORION-4: A double-blind randomized placebo-controlled trial assessing the effects of inclisiran on clinical outcomes among people with atherosclerotic cardiovascular disease: Trial design, recruitment, and baseline characteristics
Aug 7, 2026 · The American journal of medicine
Consumption of Ultra-Processed Foods and Increased Risks of Prostate Cancer in a Random Sample of United States Adults
Aug 7, 2026 · JACC. Clinical electrophysiology
The Emergence of Sports Electrophysiology: Care of Athletes With Arrhythmias, From the ACC's Sports and Exercise Cardiology Leadership Council
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
