July 29, 2026 · Journal of the American College of Cardiology · DOI: 10.1016/j.jacc.2026.05.028

Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients

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The authors aimed to investigate how evidence regarding anticoagulation for noncritically ill hospitalized COVID-19 patients was generated and translated into clinical guidelines, utilizing randomized controlled trials (RCTs) as a case study. They found that while therapeutic-dose anticoagulation was associated with reduced odds of organ support or death, delays in coordination and data sharing impeded timely translation of evidence into practice. The study emphasizes the need for improved research networks and data synthesis to enhance responsiveness during public health emergencies.

Tobias Tritschler, Valentin Fuster, Patrick R Lawler, Michael E Farkouh, Caterina E Marx, Matthew D Neal, Michelle Sholzberg, Alex C Spyropoulos, Steven Y C Tong, Nuria Muñoz-Rivas, Marc Blondon, Jeffrey S Berger, Behnood Bikdeli, Marco Cattaneo, Mary Cushman, Mark Goldin, Ewan C Goligher, Judith S Hochman, Peter Jüni, Zoe K McQuilten, Nuccia Morici, Parham Sadeghipour, Balasubramanian Venkatesh, Stéphane Zuily, Alain Amstutz, Drahomir Aujesky, Marc Carrier, Robin V Hofstetter, Srinivas Murthy, Marc Rodger, Leslie Skeith, Areti A Veroniki, Brian Hutton, Ryan Zarychanski, Gregg W Stone, Grégoire Le Gal, Anticoagulation in COVID-19 Investigators

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Timing, Translation, and Preparedness: Lessons Learned From COVID-19 Anticoagulation in Noncritically Ill Hospitalized Patients

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