International study of Coronary Microvascular Angina (iCorMicA): a registry-based diagnostic study and nested randomized trial
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The iCorMicA study aims to investigate the causes of angina in patients with no obstructive coronary artery disease (ANOCA) and to evaluate the impact of coronary function test-guided management on clinical outcomes. This international, multicenter registry-based study includes a nested randomized trial to assess changes in angina severity, as measured by the Seattle Angina Questionnaire, over 12 months. By analyzing data from 1483 participants, the study seeks to provide insights into the natural history of angina and optimize treatment strategies for affected individuals.
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