July 2, 2026 · American heart journal · DOI: 10.1016/j.ahj.2026.107518

Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial

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The authors aim to investigate the prevalence of coronary microvascular dysfunction in patients with suspected Myocardial Infarction with No Obstructive Coronary Arteries (MINOCA) and to evaluate the efficacy of eplerenone as a treatment for those identified with this dysfunction. This multicenter, registry-based study will assess coronary microvascular function and randomize patients to receive either eplerenone or standard care, with the goal of providing new insights into targeted therapy for this patient population.

Robert Sykes, Dylan Tan, Gemma McKinley, David Carrick, Daniel Ang, Andrew P Apps, Conor Bradley, Richard A Brogan, Jaclyn Carberry, Damien G Collison, Hany Eteiba, Pamela Gildea, Angie Ghattas, Aisha Gohar, Richard I S Good, Rebecca Hanna, Louise Jamieson, Francis R Joshi, Anna L Kamdar, Mitchell M Lindsay, Peter J McCartney, Richard McFarlane, Marianne McMenamin, Andrew J Morrow, Vanessa Orchard, Keith E Robertson, Paul J Rocchiccioli, Aadil Shaukat, Evangelos Tzolos, Andrea Vicere, Stuart Watkins, Mary Galbraith, Harmony Reynolds, Alex McConnachie, Colin Berry

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Stratified Medicine with Eplerenone for Myocardial Infarction or Injury and No obstructive Coronary Arteries: A Registry-Based Basket Trial

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