Intraoperative Zoledronic Acid for Arthroscopic Rotator Cuff Repair Results in Distinct Circulating Micro-RNA Profiles Indicating Improved Tendon-to-Bone Healing
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The authors aimed to investigate the effects of a single dose of zoledronic acid on circulating micro-RNA (miRNA) profiles in patients undergoing arthroscopic rotator cuff repair, particularly in relation to tendon-to-bone healing. Their findings indicate that zoledronic acid treatment is associated with distinct changes in miRNA levels that may reduce inflammation and fibrosis, enhancing collagen synthesis and vascularization at the repair site. This suggests that zoledronic acid could serve as a beneficial adjunct therapy for improving surgical outcomes in these patients.
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