Benzylpenicillin versus flucloxacillin or cloxacillin for the treatment of penicillin-susceptible Staphylococcus aureus bacteraemia (SNAP): an international, multicentre, open-label, non-inferiority randomised controlled trial
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The authors aimed to compare the efficacy and safety of benzylpenicillin versus anti-staphylococcal penicillins (flucloxacillin or cloxacillin) in treating penicillin-susceptible Staphylococcus aureus bacteraemia in adults. Although the study did not meet the prespecified non-inferiority criterion for mortality, benzylpenicillin demonstrated a high probability of non-inferiority and a significantly lower risk of acute kidney injury, suggesting it may be the preferred treatment option.
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