June 17, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102132

Improvement in chronic lymphedema in a gynecologic cancer survivor after starting GLP-1 receptor agonist therapy: A case report

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This case report investigates the potential benefits of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in treating chronic lower extremity and pelvic lymphedema in a gynecologic cancer survivor. The authors present a patient with severe lymphedema who experienced significant improvement in symptoms and quality of life after starting GLP-1 RA therapy, suggesting that these medications may offer a new treatment avenue for this challenging condition. The report highlights the need for further research to explore the effectiveness of GLP-1 RAs in managing lower extremity lymphedema.

Andrea Fromson, Christelle David, Cody C Andrews, Subha Hanif

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