June 17, 2026 · Gynecologic oncology reports · DOI: 10.1016/j.gore.2026.102125

Vaginal cancer in the second trimester of pregnancy: Successful conservative surgery and 21-year disease-free survival

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The authors investigate the management of primary vaginal cancer diagnosed during pregnancy, a rare condition with no standardized treatment protocols. They present a case of a 38-year-old woman who underwent successful conservative surgery in the second trimester, leading to a healthy delivery and 21 years of disease-free survival, suggesting that careful selection and multidisciplinary decision-making can facilitate effective treatment while preserving fetal health.

Wiebren Tjalma, Frédéric Caris Alias Reynders, Christa Eelen, Justin Konje, Filip Deckers, Ines Joye, Konstantinos Papadimitriou, Anbukkani Subbian

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