Diagnostic Strategies After Negative Colposcopy in High-Grade Cervical Cytology: A Multicenter Randomized Trial
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The authors aimed to compare different diagnostic strategies for detecting high-grade cervical lesions (HSIL+) in women with high-grade cytology results and negative colposcopy. Their multicenter randomized trial found that HPV testing combined with liquid-based cytology (LBC) offered a balanced approach, while adding endocervical brushing significantly increased sensitivity for detecting HSIL+ cases, albeit with a reduction in specificity. Overall, the study suggests that these combined strategies can enhance diagnostic safety in this patient population.
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