June 16, 2026 · Radiology · DOI: 10.1148/radiol.252706

Hybrid Cardiac <sup>68</sup>Ga-FAPI-4 PET/MRI in Dilated Cardiomyopathy: A Feasibility and Pilot Study

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This study aimed to evaluate the feasibility and performance of a hybrid cardiac ^68Ga-FAPI-4 PET/MRI protocol in patients with nonischemic dilated cardiomyopathy (DCM). The results demonstrated that the protocol effectively distinguished DCM patients from healthy controls and oncology patients, with significant correlations between FAPI uptake and various cardiac MRI metrics, suggesting its potential for simultaneous molecular and structural imaging in myocardial diseases.

Yaqiong Zhou, Hua Lin, Chuan Huang, Yangjie Li, Yuanwei Xu, Hui Wang, Jiajun Guo, Ke Wan, Jie Wang, Ziqian Xu, Weihao Li, Qing Zhang, Yuchi Han, Chunchao Xia, Xiaohong Ou, Yucheng Chen

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