June 12, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2600526

Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock

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The study aimed to determine whether sodium bicarbonate administration in critically ill adults with metabolic acidosis receiving vasopressors would reduce the risk of major adverse kidney events within 30 days compared to a placebo. The results indicated no significant difference in the occurrence of these events between the sodium bicarbonate group and the placebo group, suggesting that sodium bicarbonate does not provide a renal protective benefit in this patient population.

SODa-BIC Investigators and the Australian and New Zealand Intensive Care Society Clinical Trials Group, Ary Serpa Neto, Mairead McNamara, Kyle White, D Jamie Cooper, Tomoko Fujii, Alisa M Higgins, Carol L Hodgson, Leanlove Navarra, Alistair Nichol, Sandra Peake, Alvaro Réa-Neto, Paul Secombe, Fiona Osborne, Hugh Burrill, Emily See, Meredith Young, Fernando G Zampieri, Mark Plummer, Connor Christie, Leo Nunnink, Josephine Mackay, Shay McGuinness, Joradee Marmol, Ravindranath Tiruvoipati, Michael Bailey, Paul J Young, Rinaldo Bellomo, Andrew Udy

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Sodium Bicarbonate for Critically Ill Adults with Metabolic Acidosis and Shock

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