June 5, 2026 · Neurocritical care · DOI: 10.1007/s12028-026-02562-8

The Role of Microbiome-Associated Metabolites and Their Clinical Implications in Traumatic Brain Injury: A Scoping Review

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This scoping review investigates the role of microbiome-associated metabolites in the context of traumatic brain injury (TBI) and their potential clinical implications. The authors aim to synthesize existing preclinical and clinical data on how alterations in the gut microbiome and its metabolites may influence injury recovery and secondary injury processes in TBI patients. They also highlight knowledge gaps and propose future research directions to explore targeted microbiome interventions as a means to improve recovery outcomes.

Amanda M Dave, Mona Chatrizeh, Michael S Wolf, Michael J Morowitz, Dennis W Simon

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