June 11, 2026 · Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · DOI: 10.1097/WNP.0000000000001273

Low-Frequency Repetitive Nerve Stimulation in Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome

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The authors aimed to systematically compare low-frequency repetitive nerve stimulation patterns in patients with Lambert-Eaton myasthenic syndrome (LEMS) and myasthenia gravis (MG) to identify unique features that could aid in differential diagnosis. They found that LEMS exhibited distinct patterns, including delayed nadir, early decrement with postnadir recovery, and direct facilitation, which differ from the patterns observed in MG. These findings suggest that specific low-frequency stimulation responses can enhance diagnostic accuracy between these two conditions.

Qingyun Ding, Shuang Wu, Youfang Hu, Yimin Wu, Ying Tan, Liying Cui, Yuzhou Guan

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