TMR and RPNI Sustainably Reduce Long-Term Pain and Opioid Use after Oncologic Amputation: A Comparison With Untreated Amputees

This study investigates the long-term effectiveness of targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) in reducing chronic pain and opioid use in oncologic amputees compared to untreated patients. The findings reveal that patients who underwent TMR/RPNI experienced significantly lower levels of residual limb pain, phantom limb pain, and reduced reliance on opioids and benzodiazepines over a follow-up period of at least 10 months. The results suggest that physiologic nerve reconstruction may provide sustained pain relief and promote safer analgesic practices in post-amputation care.