June 9, 2026 · The Journal of head trauma rehabilitation · DOI: 10.1097/HTR.0000000000001188

The Feasibility and Efficacy of a Virtual, Symptom-Guided Aerobic Exercise Intervention to Improve Cognition in Mild Traumatic Brain Injury: A Single-Blind Pilot Randomized Control Trial With an Active Comparator Group

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This pilot randomized controlled trial aimed to assess the feasibility and preliminary efficacy of a 12-week virtual, symptom-guided aerobic exercise intervention for improving cognition in adults with mild traumatic brain injury (mTBI). The study found that the intervention was safe and well-adhered to, with participants in the aerobic exercise group showing significant improvements in executive function and sleep quality compared to a balance control group. These results suggest that virtual aerobic exercise may be beneficial for cognitive recovery post-mTBI, warranting further investigation in a larger trial.

Emma M Tinney, Mark C Nwakamma, Goretti España-Irla, Lauren Kong, Colette Chen, Jeremy Hwang, Amanda O'Brien, Madeleine L Perko, Ryan Luke Sodemann, Jacqueline Caefer, Julia Manczurowsky, Charles H Hillman, Alexandra M Stillman, Timothy P Morris

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