Polygenic risk impacts lifetime risk and prognosis of glaucoma
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The authors aimed to evaluate the clinical utility of a glaucoma polygenic risk score (PRS) in assessing glaucoma risk, age at onset, and prognosis in a large cohort of individuals. They found that the best-performing PRS significantly stratified lifetime glaucoma risk and correlated with the need for more intensive glaucoma care, outperforming family history alone. These results suggest that PRS could enhance screening and management strategies for glaucoma, warranting further prospective studies.
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